研究業績 (○:野中准教授著書 太字:代表著書)

 
2021

Kawade H, Morise J, Mishra SK, Tsujioka S, Oka S, Kizuka Y.
Tissue-specific regulation of HNK-1 biosynthesis by bisecting GlcNAc.
Molecules, 26, 5176. (2021)

○Yoneyama T, Hatakeyama S, Sutoh-Yoneyama M, Yoshiya T, Uemura T, Ishizu T, Suzuki M, Hachinohe S, Ishiyama S, Nonaka M, Fukuda MN, Ohyama C.
Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy.
BMC Cancer, 21, 72. (2021)

○Nonaka M, Mabashi-Asazuma H, Jarvis DL, Yamasaki K, Akama TO, Nagaoka M, Sasai T, Kimura-Takagai I, Suwa Y, Yaegashi T, Huang CT, Nishizawa-Harada C, Fukuda MN.
Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides.
PLoS One, 16, e0241157. (2021)


――――――― Review Articles ―――――――

森瀬 譲二
脳発達に伴う硫酸化糖鎖HNK-1の機能的役割
生化学, 93, 532-535. (2021)

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2020

○Nonaka M, Suzuki-Anekoji M, Nakayama J, Mabashi-Asazuma H, Jarvis DL, Yeh JC, Yamasaki K, Akama TO, Huang CT, Campos AR, Nagaoka M, Sasai T, Kimura-Takagi I, Suwa Y, Yaegashi T, Shibata TK, Sugihara K, Nishizawa-Harada C, Fukuda M, Fukuda MN.
Overcoming the blood-brain barrier by Annexin A1-binding peptide to target brain tumours.
Br J Cancer, 123, 1633-1643. (2020)

*Morise J, *Yamamoto S, Midorikawa R, Takamiya K, Nonaka M, Takematsu H, Oka S.
Distinct cell surface expression patterns of N-glycosylation site mutants of AMPA-type glutamate receptor under the homo-oligomeric expression conditions.
Int J Mol Sci, 21, 5101. (2020) *These authors contributed equally to this work.

○Nonaka M, Matsumoto S, Ma BY, Kido H, Kawasaki N, Kawasaki N, Kawasaki T.
Glycan-dependent and -independent dual recognition between DC-SIGN and typeII serin protease MSPL/TMPRSS13 in colorectal cancer cells.
Appl Sci, 10, 2687. (2020)

Midorikawa R, Takakura D, Morise J, Wakazono Y, Kawasaki N, Oka S, Takamiya K.
Monitoring the glycosylation of AMPA (a-amino-3-hydroxy-5-methyl-4isoxazole-propionate)-type glutamate receptors using specific antibodies reveals a novel regulatory mechanism of N-glycosylation occupancy by molecular chaperones in Mice.
J Neurochem, 153, 567-585. (2020)

Matsui T, Hamada Y, Kuwahara M, Morise J, Oka S, Kaida K, Kusunoki S.
Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy.
J Neuroimmunol, 339, 577127. (2020)

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2019

Morise J, Suzuki K, Kitagawa A, Wakazono Y, Takamiya K, Tsunoyama T, Nemoto Y, Takematsu H, Kusumi A, Oka S
AMPA receptors in the synapse turnover by monomer diffusion.
Nat Commun, 10, 5245. (2019)

Takagaki S, Yamashita R, Hashimoto N, Sugihara K, Kanari K, Tabata K, Nishie T, Oka S, Miyanishi M, Naruse C, Asano M.
Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow.
Sci Rep, 9, 7133. (2019)

*Nakamura A, *Morise J, Yabuno-Nakagawa K, Hashimoto Y, Takematsu H, Oka S.
Site-specific HNK-1 epitope on alternatively spliced fibronectin type-III repeats in tenascin-C promotes neurite outgrowth of hippocampal neurons through contactin-1.
PLoS One, 14, e0210193 (2019) *These authors contributed equally to this work.

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2018

*Kandel MB, *Yamamoto S, Midorikawa R, Morise J, Wakazono Y, Oka S, Takamiya K.
N-glycosylation of the AMPA-type glutamate receptor regulates cell surface expression and tetramer formation affecting channel function.
J Neurochem, 147, 730-747. (2018) *These authors contributed equally to this work.

Tomioka M, Shimobayashi M, Kitabatake M, Ohno M, Kozutsumi Y, Oka S, Takematsu H.
Ribosomal protein uS7/Rps5 serine-223 in protein kinase-mediated phosphorylation and ribosomal small subunit maturation.
Sci Rep, 8, 1244. (2018)

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2017

Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto , Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T.
MiR30-GALNT1/2 axis-mediated glycosylation contributes to the increased secretion of inactive human prohormone for brain natriuretic peptide (proBNP) from failing hearts.
J Am Heart Assoc, 6, e003601. (2017)

――――――― Review Articles ―――――――

Morise J, Takematsu H, Oka S.
The role of human natural killer-1 (HNK-1) carbohydrate in neuronal plasticity and disease.
Biochim Biophys Acta, 1861, 2455-2461. (2017)

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2016

Kouno T, Akiyama N, Fujieda K, Nanchi I, Okuda T, Iwasaki T, Oka S, Yukioka H.
Reduced intake of carbohydrate prevents the development of obesity and impaired glucose metabolism in ghrelin O-acyltransferase knockout mice.
Peptides, 86, 145-152. (2016)

Watanabe H, Okahara K, Naito-Matsui Y, Abe M, Go S, Inokuchi J, Okazaki T, Kobayashi T, Kozutsumi Y, Oka S, Takematsu H.
Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5 bisphosphate production at the cleavage furrow.
Mol Biol Cell, mbc.E15-08-0555. (2016)

Kouno T, Akiyama N, Ito T, Okuda T, Nanchi I, Notoya M, Oka S, Yukioka H.
Ghrelin O-acyltransferase knockout mice show resistance to obesity when fed high-sucrose diet
J Endocrinol, 228, 115-125. (2016)


  ――――――― Review Articles ―――――――

○Nonaka M.
Function of the glycosyltransferase GnT-V in colitis.
J Gastroenterol, 51, 406-408 (2016).

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2015

Yabuno K, Morise J, Kizuka Y, Hashii N, Kawasaki N, Takahashi S, Miyata S, Izumikawa T, Kitagawa H, Takematsu H, Oka S.
A sulfated glycosaminoglycan linkage region is a novel type of human natural killer-1 (HNK-1) epitope expressed on aggrecan in perineuronal nets
PLoS One, 10, e0144560. (2015)

*Takeuchi Y, *Morise J, Morita I, Takematsu H, Oka S.
Role of site-specific N-glycans expressed on GluA2 in the regulation of cell surface expression of AMPA-type glutamate receptors.
PLoS One, 10, e0135644. (2015) *These authors contributed equally to this work.

Gu W, Fukuda T, Isaji T, Hang Q, Lee HH, Sakai S, Morise J, Mitoma J, Higashi H, Taniguchi N, Yawo H, Oka S, Gu J.
Loss of α1,6-fucosyltransferase decreased hippocampal long-term potentiation: implications for core fucosylation in the regulation of AMPA receptor heteromerization and cellular signaling.
J Biol Chem, 290, 17566-17575. (2015)

Nakagawa N, Yagi H, Kato K, Takematsu H, Oka S.
Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.
Sci Rep, 5, 11163. (2015)

Hamada Y, Hirano M, Kuwahara M, Samukawa M, Takada K, Morise J, Yabuno K, Oka S, Kusunoki S.
Binding specificity of anti-HNK-1 IgM M-protein in anti-MAG neuropathy: Possible clinical relevance.
Neurosci Res, 91, 63-68. (2015)

Yaji S, Manya H, Nakagawa N, Takematsu H, Endo T, Kannagi R, Yoshihara T, Asano M, Oka S.
Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannnose-linked glycans on phosphacan/RPTPβ.
Glycobiology, 25, 376-385. (2015)

○Matsumoto S, Nakao H, Kawabe K, Nonaka M, Toyoda H, Takishima Y, Kawabata K, Yamaguchi T, Furue MK, Taki T, Okumura T, Yamazaki Y, Nakaya S, Kawasaki N, Kawasaki T.
A cytotoxic antibody recognizing lacto-N-fucopentaose I (LNFP I) on human induced pluripotent stem (hiPS) cells.
J Biol Chem, 290, 20071-20085. (2015)

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2014

Akasaka-Manya K, Manya H, Kizuka Y, Oka S, Endo T
α-Klotho mice demonstrate increased expression of the non-sulfated N-glycan form of the HNK-1 glyco-epitope in kidney tissue.
J Biochem, 156, 107-113.(2014)

Morise J, Kizuka Y, Yabuno K, Tonoyama Y, Hashii N, Kawasaki N, Manya H, Miyagoe-Suzuki Y, Takeda S, Endo T, Maeda N, Takematsu H, Oka S.
Structural and biochemical characterization of O-mannose-linked HNK-1 glycan expressed on phosphacan in developing mouse brains.
Glycobiology, 24, 314-24. (2014)

○Nonaka M, Bao X, Matsumura F, Gotze S, Kandasamy J, Kononov A, Broide DH, Nakayama J, Seeberger PH, Fukuda M.
Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites.
Proc Natl Acad Sci U S A, 111, 8173-8178. (2014)

○Nonaka M, Fukuda MN, Gao C, Li Z, Zhang H, Greene MI, Peehl DM, Feizi T, Fukuda M.
Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes.
J Biol Chem, 289, 16478-16486. (2014)

○Gao C, Liu Y, Zhang H, Zhang Y, Fukuda MN, Palma AS, Kozak RP, Childs RA, Nonaka M, Li Z, Siegel DL, Hanfland P, Peehl DM, Chai W, Greene MI, Feizi T.
Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array.
J Biol Chem, 289, 16462-16477. (2014)

○Nonaka M, Imaeda H, Matsumoto S, Yong Ma B, Kawasaki N, Mekata E, Andoh A, Saito Y, Tani T, Fujiyama Y, Kawasaki T.
Mannan-binding protein, a C-type serum lectin, recognizes primary colorectal carcinomas through tumor-associated Lewis glycans.
J Immunol, 192, 1294-1301.(2014)

Yamane-Sando Y, Shimobayashi E, Shimobayashi M, Kozutsumi Y, Oka S, Takematsu H.
Fpk1/2 kinases regulate cellular sphingoid long-chain base (LCB) abundance and alter cellular resistance to LCB elevation or depletion.
Microbiology Open, 3, 196-212. (2014)


  ――――――― Review Articles ―――――――

Nakagawa N, Oka S.
HNK-1 glyco-epitope: COMPLEX machinery for the biosynthesis.
Glycoscience: Biology and Medicine, 543-549. (2014)

○Nonaka M, Kawasaki T.
Functional assay using lectin gene targeting technologies (over-expression).
Methods Mol Biol, 1200, 389-399. (2014)

Kizuka Y, Oka S.
Beta-1,3-Glucuronyltransferase 1 (Glucuronosyltransferase P); Beta-1,3-Glucuronyltransferase 2 (B3GAT1,2)
Handbook of Glycosyltransferases and Related Genes, 2nd Ed, 835-847. (2014)

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2013

Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, Takematsu H.
Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.
J Biol Chem, 289, 1564-1579. (2013)

*Yagi H, *Nakagawa N, Saito T, Kiyonari H, Abe T, Toda T, Wu SW, Khoo KH, Oka S, Kato K.
AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.
Sci Rep, 21, 3288. (2013) *These authors contributed equally to this work.

Nakagawa N, Takematsu H, Oka S.
HNK-1 sulfotransferase-dependent sulfation regulating laminin-binding glycans occurs in the post-phosphoryl moiety on α-dystroglycan.
Glycobiology, 23, 1066-1074. (2013)


○Kawabe K, Tateyama D, Toyoda H, Kawasaki N, Hashii N, Nakao H, Matsumoto S, Nonaka M, Matsumura H, Hirose Y, Morita A, Katayama M, Sakuma M, Kawasaki N, Furue MK, Kawasaki T.
A novel antibody for human induced pluripotent stem cells and embryonic stem cells recognizes a type of keratan sulfate lacking oversulfated structures.
Glycobiology, 23, 322-336. (2013)

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2012

Nakagawa N, Manya H, Toda T, Endo T, Oka S.
Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on α-dystroglycan.
J Biol Chem, 287, 30823-30832. (2012)


Hirano M, Ma BY, Kawasaki N, Oka S, Kawasaki T.
Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney
Glycobiology, 22, 84-95. (2012)

――――――― Review Articles ―――――――

Kizuka Y, Oka S
Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate.
Cell Mol Life Sci, 69, 4135-4147. (2012)


○Nonaka M, Fukuda M.
Galectin-1 for neuroprotection?
Immunity, 37, 187-189. (2012)

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2011

Nakagawa N, Izumikawa T, KitagawaH, Oka S.
Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin.
Biochem Biophys Res Commun, 415, 109-113. (2011)


Kouno T, Kizuka Y, Nakagawa N, Yoshihara T, Asano M, Oka S.
Specific enzyme complex of beta-1, 4-galactosyltransferase-II and GlcAT-P facilitates biosynthesis of N-linked HNK-1 carbohydrate.
J Biol Chem, 286, 31337-31346. (2011)


○Nonaka M, Ma BY, Imaeda H, Kawabe K, Kawasaki N, Hodohara K, Kawasaki N, Andoh A, Fujiyama Y, Kawasaki T.
Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas.
J Biol Chem, 286, 22403-22413. (2011)


――――――― Review Articles ―――――――

Kizuka Y, Nakagawa N, Morita I, Oka S.
Requirement of acidic amino acids in the Glucuronyltransferase-P (GlcAT-P) flexible loop for its enzyme activity.
Glycans: Biochemistry, Characterization and Applications, (2011)


森瀬 譲二、森田 一平、岡 昌吾
HNK-1糖鎖によるグルタミン酸受容体の発現レベルの調節
生化学, 83, 205-211. (2011)

中川 直樹、森田 一平、岡 昌吾
HNK-1糖鎖抗原と神経突起の形成
脳21, 14, 37-43. (2011)

岡 昌吾
HNK-1糖鎖合成酵素(グルクロン酸転移酵素)
生物機能モデルと新しいリソース・リサーチツール, 321-326. (2011)

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2010

――――――― Review Articles ―――――――

Kizuka Y, Oka S.
Regulation of HNK-1 (Human Natural Killer-1) Carbohydrate Expression: Multiple Control Mechanisms of Biosynthetic Enzyme Activity.
Trends Glycosci. Glycotechnol., 22, 194-199. (2010)

岡 昌吾
記憶学習に関与する糖鎖
臨床化学, 39, 381-382. (2010)

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2009

Morita I, Kakuda S, Takeuchi Y, Kawasaki T, Oka S.
HNK-1 (human natural killer-1) glyco-epitope is essential for normal spine morphogenesis in developing hippocampal neurons.
Neuroscience, 164, 1685-1694. (2009)


Morita I, Kakuda S, Takeuchi Y, Itoh S, Kawasaki N, Kizuka Y, Kawasaki T, Oka S.
HNK-1 glyco-epitope regulates the stability of the glutamate receptor subunit GluR2 on the neuronal cell surface.
J Biol Chem, 284, 30209-30217. (2009)


Anzai D, Tonoyama Y, Ikeda A, Kawasaki T, Oka S.
Regulated expression of the HNK-1 carbohydrate is essential for medaka (Oryzias latipes) embryogenesis.
Glycobiology, 19, 868-878. (2009)


Tonoyama Y, Anzai D, Ikeda A, Kakuda S, Kinoshita M, Kawasaki T, Oka S.
Essential role of beta 1,4-galactosyltransferase 2 during medaka (Oryzias latipes) gastrulation.
Mech Dev, 126, 580-594. (2009)


Yoshihara T, Sugihara K, Kizuka Y, Oka S, Asano M.
Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta 4-galactosyltransferase-II-deficient mice.
J Biol Chem, 284, 12550-12561. (2009)

Kizuka Y, Tonoyama Y, Oka S.
Distinct transport and intracellular activities of two GlcAT-P isoforms.
J Biol Chem, 284, 9247-9256. (2009)


Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T.
Highly fucosylated N-glycan ligands for mannan-binding protein expressed specifically on CD26 (DPPVI) isolated from a human colorectal carcinoma cell line, SW1116.
Glycobiology, 19, 437-450. (2009)

○Nakamura N, Nonaka M, Ma BY, Matsumoto S, Kawasaki N, Asano S, Kawasaki T.
Characterization of the interaction between serum mannan-binding protein and nucleic acid ligands.
J Leukoc Biol., 86, 737-748. (2009)

○Ma BY, Yoshida K, Baba M, Nonaka M, Matsumoto S, Kawasaki N, Asano S, Kawasaki T.
The lectin Jacalin induces human B-lymphocyte apoptosis through glycosylation-dependent interaction with CD45.
Immunology,127, 477-488. (2009)

――――――― Review Articles ―――――――

Kizuka Y, Tonoyama Y, Oka S.
Functional Enzyme Complex Involved in HNK-1 Carbohydrate Biosynthesis.
Glycobiology Research Trends, 173-187. (2009)

Tonoyama Y, Oka S
Cell trace experiment with a caged fluorescent dye during medaka gastrulation.
Medaka: Biology, Management, and Experimental Protocols, 382-388. (2009)

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2008

Kizuka Y, Kobayashi K, Kakuda S, Nakajima Y, Itoh S, Kawasaki N, Oka S.
Laminin-1 is a novel carrier glycoprotein for the non-sulfated HNK-1 epitope in mouse kidney.
Glycobiology, 18, 331-338. (2008)


○Nonaka M, Ma BY, Murai R, Nakamura N, Baba M, Kawasaki N, Hodohara K, Asano S, Kawasaki T.
Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells.
J Immunol, 180, 3347-3356. (2008)


Yagi H, Yamada K, Ohno E, Utsumi M, Yamaguchi Y, Kurimoto E, Takahashi N, Oka S, Kawasaki T, Kato K.
Development and application of high performance liquid chromatography map of glucuronyl N-glycans.
Open Glycoscience, 1, 8-18. (2008)

――――――― Review Articles ―――――――

Kakuda S, Kawasaki T, Oka S.
Glucuronyltransferases Involved in the HNK-1 Biosynthesis.
Experimental Glycoscience (Glycobiology), 47-49. (2008)

Kizuka Y, Oka S.
Functional Roles of the HNK-1 Carbohydrate and Polysialic Acid in the Nervous System.
Experimental Glycoscience (Glycobiology), 180-181. (2008)

Morita I, Oka S.
Glucuronyltransferase(GlcAT-P) Gene-Deficient Mice.
Experimental Glycoscience (Glycobiology), 381-382. (2008)

Morita I, Kizuka Y, Kakuda S, Oka S.
Expression and function of the HNK-1 carbohydrate.
J Biochem, 43, 719-724. (2008)

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2007

Inoue M, Kato K, Matsuhashi H, Kizuka Y, Kawasaki T, Oka S.
Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene.
Brain Res, 1179, 1-15. (2007)


○Nonaka M, Ma BY, Ohtani M, Yamamoto A, Murata M, Totani K, Ito Y, Miwa K, Nogami W, Kawasaki N, Kawasaki T.
Subcellular localization and physiological significance of intracellular mannan-binding protein.
J Biol Chem, 282, 17908-17920. (2007)


○Ma BY, Nakamura N, Dlabac V, Naito H, Yamaguchi S, Ishikawa M, Nonaka M, Ishiguro M, Kawasaki N, Oka S, Kawasaki T.
Isolation, cloning, and characterization of a novel phosphomannan-binding lectin from porcine serum.
J Biol Chem, 282, 12963-12975. (2007)

○Ma BY, Kaihama M, Nonaka M, Oka S, Kawasaki N, Kawasaki T.
LPS suppresses expression of asialoglycoprotein-binding protein through TLR4 in thioglycolate-elicited peritoneal macrophages.
Glycoconj J, 24, 243-249. (2007)

○Baba M, Ma BY, Nonaka M, Matsuishi Y, Hirano M, Nakamura N, Kawasaki N, Kawasaki N, Kawasaki T.
Glycosylation-dependent interaction of Jacalin with CD45 induces T lymphocyte activation and Th1/Th2 cytokine secretion.
J Leukoc Biol, 81, 1002-1011. (2007)

――――――― Review Articles ―――――――

岡 昌吾、木塚 康彦、角田 品子
糖タンパク質による神経調節
実験医学増刊, 25, 110-114. (2007)

岡 昌吾
神経機能と糖鎖
バイオサイエンスとインダストリー, 65, 22-23. (2007)

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2006

Shiba T, Kakuda S, Ishiguro M, Morita I, Oka S, Kawasaki T, Wakatsuki S, Kato R.
Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope.
Proteins, 65, 499-508. (2006)

Kizuka Y, Matsui T, Takematsu H, Kozutsumi Y, Kawasaki T, Oka S.
Physical and functional association of glucuronyltransferases and sulfotransferase involved in HNK-1 biosynthesis.
J Biol Chem, 281, 13644-13651. (2006)

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2005

Hirano M, Ma BY, Kawasaki N, Okimura K, Baba M, Nakagawa T, Miwa K, Kawasaki N, Oka S, Kawasaki T.
Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta.
J Immunology, 175, 3177-3185. (2005)

Tagawa H, Kizuka Y, Ikeda T, Itoh S, Kawasaki N, Kurihara H, Onozato ML, Tojo A, Sakai T, Kawasaki T, Oka S.
Non-sulfated form of the HNK-1 carbohydrate is expressed in mouse kidney.
J Biol Chem, 280 23876-23883. (2005)


Terada M, Khoo KH, Inoue R, Chen CI, Yamada K, Sakaguchi H, Kadowaki N, Ma BY, Oka S, Kawasaki T, Kawasaki N.
Characterization of oligosaccharide ligands expressed on SW1116 cells recognized by mannan-binding protein a highly fucosylated polylactosamine type N-glycan.
J Biol Chem, 280, 10897-10913. (2005)

Kakuda S, Sato Y, Tonoyama Y, Oka S, Kawasaki T.
Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.
Glycobiology, 15, 203-210. (2005)

――――――― Review Articles ―――――――

岡 昌吾
HNK-1糖鎖生合成に関与するグルクロン酸転移酵素遺伝子(p160-161)
神経系におけるHNK-1糖鎖とポリシアル酸の機能(p238-140)
GlcAT-P遺伝子ノックアウトマウスによる糖鎖機能の解明(p390-391)
未来を拓く糖鎖科学, (2005)

岡 昌吾、田川 秀樹、川嵜 敏祐
遺伝子医学(病気と糖鎖) HNK-1糖鎖
メディカルドゥ, 175-179. (2005)

田川 秀樹、岡 昌吾、川嵜 敏祐
HNK-1糖鎖と高次神経機能 
糖鎖科学の新展開(機能解明・次世代型材料・医薬品開発に向けて), 208-215. (2005)

岡 昌吾、角田 品子、川嵜 敏祐
記憶学習機能における糖鎖修飾の関与
生化学, 77, 491-497. (2005)

志波 智生、角田 品子、岡 昌吾、石黒 正路、川嵜 敏祐、若槻 壮市、加藤 龍一
HNK-1糖鎖の生合成に必須な糖転移酵素GlcAT-Pの糖鎖基質認識機構
生化学, 77, 153-158. (2005)

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2004

Uemura K, Yamamoto H, Nakagawa T, Nakamura K, Kawasaki N, Oka S, Ma BY, Kawasaki T.
Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP).
Glycoconj J, 21, 79-84. (2004)

Kakuda S, Shiba T, Ishiguro M, Tagawa H, Oka S, Kajiwara Y, Kawasaki T, Wakatsuki S, Kato R.
Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1.
J Biol Chem, 279, 22693-22703. (2004)

Kakuda S, Oka S, Kawasaki T.
Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli.
Protein Expr Purif, 35, 111-119. (2004)

――――――― Review Articles ―――――――

角田 品子、岡 昌吾、川嵜 敏祐
HNK-1糖鎖欠損マウスにおける学習障害
蛋白質核酸酵素, 49, 2431-2436. (2004)

井上 満博、岡 昌吾、川嵜 敏祐
神経系ネットワーク形成における糖鎖シグナルの役割
実験医学, 22, 946-950. (2004)

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2003

Nakagawa T, Ma BY, Uemura K, Oka S, Kawasaki N, Kawasaki T.
Role of mannan-binding protein, MBP, in innate immunity.
Anticancer Res, 23, 4467-4471. (2003)

Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T.
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kB coordinately.
Eur J Biochem, 270, 76-83. (2003)

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沖村 一満、岡 昌吾、川嵜 敏祐
レクチン経路の癌免疫への応用
医学のあゆみ, 205, 113-116. (2003)

山本 昌司、岡 昌吾、川嵜 敏祐
酸性糖鎖の記憶学習への関与
蛋白質核酸酵素, 48, 934-939. (2003)

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2002

Yamamoto S, Oka S, Inoue M, Shimuta M, Manabe T, Takahashi H, Miyamoto M, Asano M, Sakagami J, Sudo K, Iwakura Y, Ono K, Kawasaki T.
Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning.
J Biol Chem, 277, 27227-27231. (2002)

Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T.
cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope.
Gene, 296, 29-36. (2002)

Yamamoto S, Oka S, Saito-Ohara F, Inazawa J, Kawasaki T.
Molecular cloning and genomic analysis of mouse glucuronyltransferase involved in biosynthesis of the HNK-1 epitope.
J Biochem, 131, 337-347. (2002)

Ikeda A, Sakuma H, Masaki M, Kozutsumi Y, Oka S, Inazawa J, Kawasaki T
Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene.
J Biochem Mol Biol Biophys, 6, 113-116. (2002)

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2001

Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T.
Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH2-terminal kinase pathway.
J Biochem, 130, 773-781. (2001)

Katsuyama R, Morioka A, Oka S, Kawasaki T.
Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical Ppathway.
Biochem Biophys Res Commun, 280, 1269-1273. (2001)

Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T.
Identification and characterization of functional domains in a mixed lineage kinase LZK.
FEBS Lett, 488, 190-195. (2001)

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Yamamoto S, Oka S.
Glucuronyltransferases involved in the HNK-1 carbohydrate epitope biosynthesis.
Trends Glycosci Glycotechnol, 13, 193-208. (2001)

川嵜 敏祐、岡 昌吾
神経系特異的糖鎖抗原HNK-1の役割
日本神経精神薬理学雑誌, 21, 95-99. (2001)

岡 昌吾、川嵜 敏祐
神経系における糖鎖の役割 糖鎖リモデリングによるHNK-1糖鎖の解析を中心に
細胞工学, 20, 187-192. (2001)

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2000

Oka S, Terayama K, Imiya K, Yamamoto S, Kondo A, Kato I, Kawasaki T.
The N-glycan acceptor specificity of a glucuronyltransferase, GlcAT-P, associated with biosynthesis of the HNK-1 epitope.
Glycoconj J, 17, 877-885. (2000)


Ohtsubo K, Ishiguro M, Imajo S, Nakatani T, Oka S, Kawasaki T.
Studies on the structure-function relationship of the HNK-1 associated glucuronyltransferase, GlcAT-P, by computer modeling and site directed Mmtagenesis.
J Biochem, 128, 283-291. (2000)

Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T.
Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope.
Genomics, 65, 166-173. (2000)

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1999

Natio H, Ikeda A, Hasegawa K, Oka S, Uemura K, Kawasaki N, Kawasaki T.
Characterization of human serum mannan-binding protein promoter.
J Biochem, 126, 1004-1012. (1999)

Tone Y, Kitagawa H, Imiya K, Oka S, Kawasaki T, Sugahara K.
Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
FEBS Lett, 459, 415-420. (1999)

Seiki T, Oka S, Terayama K, Imiya K, Kawasaki T.
Molecular cloning and expression of a second glucuronyltransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope.
Biochem Biophys Res Commun, 255, 182-187. (1999)

Ma Y, Uemura K, Oka S, Kozutsumi Y, Kawasaki N, Kawasaki T.
Antitumor activity of mannan-binding protein in vivo as revealed with a virus expression system: Mannan-binding protein-dependent cell-mediated cytotoxicity.
Proc Natl Acad Sci USA, 96, 371-375. (1999)

――――――― Review Articles ―――――――

岡 昌吾、川嵜 敏祐
細胞接着分子に発現するHNK-1糖鎖抗原の生物学的機能
細胞工学, 18, 357-361. (1999)

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1998

Terayama K, Nakamura A, Seiki T, Matsumori K, Ohta S, Oka S, Sugita M, Kawasaki T.
Purification and characterization of a glucuronyltransferase involved in the biosynthesis of HNK-1 epitope on glycoproteins from rat brain.
J Biol Chem, 273, 30295-30300. (1998)

Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K.
Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
J Biol Chem, 273, 6615-6618. (1998)

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岡 昌吾
神経系における細胞接着分子とこれに特異的に発現する糖鎖の分子生物学的研究
薬学雑誌, 118, 431-446. (1998)

大坪 和明、生木 尚志、岡 昌吾、川嵜 敏祐
神経系におけるHNK-1糖鎖抗原の生物学的役割
蛋白質核酸酵素, 43, 2366-2372. (1998)

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1997

Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta J, Kawasaki T.
Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain.
J Biol Chem, 272, 28622-28629. (1997)

Bakker H, Friedmann I, Oka S, Kawasaki T, Nifant’ev N, Schachner M, Mantei N.
Expression cloning of a cDNA encoding a sulfotransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope.
J Biol Chem, 272, 29942-29946 (1997).

Sakuma H, Itoh T, Oka S, Kawasaki T.
A monoclonal antibody recognizing nestin and the phosphorylated form of neurofilament-m.
Dev Neurosci, 19, 348-356. (1997)

Terayama K, Oka S, Seiki T, Miki Y, Nakamura A, Kozutsumi Y, Takio K, Kawasaki T.
Cloning and functional expression of a novel glucuronyltransferase involved in the biosynthesis of the carbohydrate epitope, HNK-1.
Proc Natl Acad Sci USA, 94, 6093-6098. (1997)

Morio H, Kurata H, Katsuyama R, Oka S, KozutsumiY, Kawasaki T.
Renal expression of serum-type mannan-binding protein in rat.
Eur J Biochem, 243, 770-774. (1997)

――――――― Review Articles ―――――――

岡 昌吾、川嵜 敏祐
神経系における細胞接着分子
ファルマシア, 33, 1223-1227. (1997)

岡 昌吾、小野 勝彦
NCAMの発現と機能(神経系におけるNCAMとポリシアル酸)
蛋白質核酸酵素, 42, 535-541. (1997)

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1995

Brusés JL, Oka S, Rutishauser U.
NCAM-associated polysialic acid on ciliary ganglion neurons is regulated by polysialyltransferase levels and interaction with muscle.
J Neurosci, 15, 8310-8319. (1995)

Oka S, Brusés JL, Nelson RW, Rutishauser U.
Properties and developmental regulation of polysialyltransferase activity in the chicken embryo brain.
J Biol Chem, 270, 19357-19363. (1995)

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1994

Yoshihara Y, Oka S, Nemoto Y, Watanabe Y, Nagata S, Kagamiyama H, Mori K.
An ICAM-related Neuronal Glycoprotein, Telencephalin, with Brain Segment-specific expression.
Neuron, 12, 541-553. (1994)

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1992

Kawashima C, Terayama K, Ii M, Oka S, Kawasaki T.
Characterization of a glucuronyltransferase: neolactotetraosylceramide glucuronyltransferase from rat brain.
Glycoconj J, 9, 307-314. (1992)

Oka S, Terayama K, Kawashima C, Kawasaki T.
A novel glucuronyltransferase in nervous system presumably associated with the biosynthesis of HNK-1 carbohydrate epitope on glycoprotein.
J Biol Chem, 267, 22711-22714. (1992)


――――――― Review Articles ―――――――

川嵜 敏祐、岡 昌吾
細胞間のコミニケーションと糖
化学増刊, 122, 57-63. (1992)

黒坂 光、岡 昌吾、脇本 公嗣、川嵜 敏祐
昆虫神経細胞に特異的に発現する糖鎖抗原
蛋白質核酸酵素, 37, 1920-1923. (1992)

岡 昌吾、中田 博、川嵜 敏祐、山科 郁男
遺伝子操作を用いた糖鎖の削除および改変
蛋白質核酸酵素, 37, 389-394. (1992)

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1991

Arita H, Hamasaki K, Nakano T, Oka S, Teraoka H, Matsumoto K.
Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells via specific binding site.
J Biol Chem, 266, 19139-19141. (1991)

Oka S, Arita H.
Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes.
J Biol Chem, 266, 9956-9960. (1991)


Yoshihara Y, Oka S, Watanabe Y, Mori K.
Developmentally and spatially regulated expression of HNK-1 carbohydrate antigen on a novel phosphatidylinositol-anchored glycoprotein in rat brain.
J Cell Biol, 115, 731-744. (1991)

Yoshihara Y, Oka S, Ikeda J,Mori K.
Immunoglobulin superfamily molecules in the nervous system.
Neurosci Res, 10, 83-105. (1991)

Takema M, Oka S, Uno K, Nakamura S, Arita H, Tawara K, Inaba K, Muramatsu S.
Macrophage-activating factor extracted from mycoplasmas.
Cancer Immunol Immunother, 33, 39-44. (1991)

Murakami F, Tada Y, Mori K, Oka S, Katsumaru H.
Ultrastructural localization of telencephalin, a telencephalon-specific membrane glycoprotein, in rabbit olfactory bulb.
Neurosci Res, 11, 141-145. (1991)

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1990

Imamura K, Mori K, Oka S, Watanabe Y.
Variations by layers and developmental changes in expression of telencephalin in the visual cortex of cat.
Neurosci Lett, 119, 118-121. (1990)

Oka S, Mori K, Watanabe Y.
Mammalian telencephalic neurons express a segment-specific membrane glycoprotein, telencephalin.
Neurosci, 35, 93-103. (1990)


Bjuling P, Watanabe Y, Oka S, Nagasawa T, Yamada H, Longstrom B.
Multi-enzymatic syntheses of 11-C-labeled L-tyrosine and L-DOPA.
Acta Chem Scand, 44, 183-188. (1990)

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1989

Ikeda J, Mori K, Oka S, Watanabe Y.
A columnar arrangement of dendritic processes of entrhinal cortex neurons revealed by a monoclonal antibody.
Brain Res, 505, 176-179. (1989)

Mori K, Oka S, Tani A, Ito S, Watanabe Y.
E-series prostaglandins activate cAMP-mediated potassium currents in follicle-enclosed Xenopus oocyte.
Biochem Biophys Res Commun, 162, 1535-1540. (1989)

――――――― Review Articles ―――――――

森 憲作、岡 昌吾
脳への分子生物学的アプローチ
生体の科学, 40, 95-100. (1989)

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1988

Oka S, Ikeda K, Kawasaki T, Yamashina I.
Isolation and characterization of two distinct mannan-binding proteins form rat serum.
Arch Biochem Biophys, 260, 257-266. (1988)

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1987

Oka S, Kawasaki T, Itoh N, Yamashina I.
Primary structure of rat mannan-binding protein deduced from its cDNA sequence.
J Biochem, 101, 135-144. (1987)

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1985

Oka S, Kawasaki T, Yamashina I.
Isolation and characterization of mannan-binding protein from chicken liver.
Arch Biochem Biophys, 241, 95-105. (1985)

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